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Department of drug chemistry

The Department of chemistry was first headed by academician RAS, professor N. K. Kochetkov (1953 - 1960), then by professor A.P. Skoldinov (1960 - 1984), professor L.D. Smirnov (1984 - 1989), professor G.G. Rozantsev (1989 - 2000).

Tatyana A. Gudasheva

Ever since 2000 Dr. Sci., Professor Tatyana A. Gudasheva is the Head of Chemistry Department.

tel.: (495) 601-2373, 601-2246

Scope of Basic Department Research activities:

The chemical studies and search for potential medicines is performed among chemical substances of the following groups:

The researchers of the Department have supported 4 Doctor Sci. and 46 Ph.D. theses.

Recent publications:

  1. R. U. Ostrovskaya, M.A. Gruden, N.A. Bobkova, R. D. E. Sewell , T. A. Gudasheva, A. N. Samokhin, S. B. Seredеnin, W.Noppe, V.V. Sherstnev, L. A. Morozova-Roche . The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model.// J Psychopharmacol 2007 vol . 21, N 6, 611-619.
  2. Design and synthesis of cholecystokinin-4 dipeptide analogues with anxiolytic and anxiogenic activities. TA Gudasheva, EP Kir'ianova, LG Kolik, MA Konstantinopol'skii, and SB Seredenin. Bioorg Khim, Jul 2007; 33(4): 413-20. [in Russ.]
  3. Eksp Klin Farmakol. 2012;75(9):15-20.Neuroprotective effects of a dipeptide mimetic on the GK-2 nerve growth factor in model of permanent common carotid artery occlusion in rats.Povarina PIu, Gudasheva TA, Vorontsova ON, Nikolaev SV, Antipova TA, Ostrovskaia RU, Seredin SB.
  4. Eksp Klin Farmakol. 2012;75(9):3-6.Similarity of cycloprolylglycine to piracetam in antihypoxic and neuroprotective effects.Kolisnikova KN, Gudasheva TA, Nazarova GA, Antipov TA, Voronina TA, Seredenin SB.
  5. Bull Exp Biol Med. 2012 Oct;153(6):851-4.Role of the cholecystokinin system in anxiolytic activity of dipeptide GB-115.Kolik LG, Gudasheva TA, Seredenin SB.
  6. Fiziol Cheloveka. 2012 Jul-Aug;38(4):102-7.Antifibrillatory activity of dipeptide antagonist of nerve growth factor.Kryzhanovskiĭ SA, Stoliarchuk VN, Vititnova MB, Tsorin IB, Pekel'dina ES, Gudasheva TA.
  7. Bioorg Khim. 2012 May-Jun;38(3):280-90.Design and synthesis of dipeptide mimetics of brain-derived neurotrophic factor.Gudasheva TA, Tarasiuk AV, Pomogaĭbo SV, Logvinov IO, Povarnina PIu, Antipova TA, Seredenin SB.
  8. Bull Exp Biol Med. 2012 Aug;153(4):468-71.Experimental study of antinociceptive potency of dipeptide GB-115 during chemical and thermal stimulation.Kolik LG, Zhukov VN, Gudasheva TA, Seredenin SB.
  9. Bioorg Khim. 2012 Jan-Feb;38(1):119-26.The search of small molecules with antipsychotic activity on the background of neurotensin.Ostrovskaia RU, Gudasheva TA, Krupina NA, Seredin SB.
  10. Bull Exp Biol Med. 2011 Oct;151(6):690-3.Antiparkinsonian properties of a nerve growth factor dipeptide mimetic GK-2 in in vivo experiments.Povarnina PY, Gudasheva TA, Vorontsova ON, Bondarenko NA, Seredenin SB.
  11. Bull Exp Biol Med. 2011 Sep;151(5):584-7.Neuroprotective effect of GK-2, a dipeptide mimetic of nerve growth factor, during experimental focal ischemia in middle cerebral artery basin.Seredenin SB, Silachev DN, Gudasheva TA, Pirogov YA, Isaev NK.
  12. Bull Exp Biol Med. 2011 Feb;150(4):432-5.Neuroprotective and antiamnestic effect of nerve growth factor dipeptide mimetic GK-2 in experimental ischemic infarction of brain cortex.Seredenin SB, Romanova GA, Gudasheva TA, Shakova FM, Barskov IV, Stelmashuk EV, Antipova TA.
  13. Eksp Klin Farmakol. 2011;74(10):7-11.Effect of GB-115 dipeptide on anxiety in rats with model benzodiazepine withdrawal syndrome.Kolik LG, Kadnikov IA, Zhukov VN, Gudasheva TA, Seredenin SB.
  14. Bull Exp Biol Med. 2011 Mar;150(5):607-9.In vitro study of neuroprotective properties of GK-2, a new original nerve growth factor mimetic.Antipova TA, Gudasheva TA, Seredenin SB.
  15. Vestn Ross Akad Med Nauk. 2011;(7):37-42.[The absence of tolerance and withdrawal syndrome after the treatment with the new L-tryptophane-containing dipeptide anxiolytic GB-115].Kolik LG, Garibova TL, Litvinova SA, Kuznetsova AL, Kapitsa IG, Kadnikov IA, Konstantinopol'skiĭ MA, Gudasheva TA, Voronina TA, Seredenin SB.
  16. Vestn Ross Akad Med Nauk. 2011;(7):8-16.Strategy for the development of dipeptide drugs.Gudasheva TA.
  17. Russ. Chem. Bull., Int. Ed. 2011, 60, №8, 1694-1702Synthesis and selected properties of N-unsubstituted pyrrolo[2,1-c]-1,3-diazacycloalkano[1,2-a]pyrazinonesMokrov, G. V.; Likhosherstov, A. M.; Lezina, V. P.; Gudasheva, T. A.; Bushmarinov, I. S.; and Antipin M. Yu.
  18. Bull Exp Biol Med. 2010 Nov;149(6):709-11.Regional and subcellular localization of cycloprolylglycine in rat brain.Boiko SS, Gudasheva TA, Vichuzhanin MV, Zherdev VP, Seredenin SB.
  19. Dokl Biochem Biophys. 2010 Sep-Oct;434:262-5. doi: 10.1134/S160767291005011X. Epub 2010 Oct 20.Novel low-molecular-weight mimetics of the nerve growth factor.Gudasheva TA, Antipova TA, Seredenin SB.
  20. Russ. Chem. Bull., Int. Ed. 2010, 59, 1254-1266Synthesis and selected properties of N-substituted pyrrolo[2,1-c]-1,3-diazacycloalkano[1,2-a]pyrazinonesMokrov, G. V.; Likhosherstov, A. M.; Lezina, V. P.; Gudasheva, T. A.; Bushmarinov, I. S.; and Antipin M. Yu.
  21. Eksp Klin Farmakol. 2009 Sep-Oct;72(5):3-7.Neurotensine dipeptide analog dilept decreases the deficiency of prestimulus startle reflex inhibition: a prognostic sign of antipsychotic activity.Ostrovskaia RU, Krupina NA, Gudasheva TA, Voronina TA, Seredenin SB.
  22. Eksp Klin Farmakol. 2009 May-Jun;72(3):16-21.Experimental pharmacokinetics of the new neurotensine-derived antipsychotic drug dilept.Zherdev VP, Boĭko SS, Mesonzhnik NV, Appolonova SA, Rodchenkov GN, Ostrovskaia RU, Gudasheva TA, Seredenin SB.
  23. Bull Exp Biol Med. 2008 Sep;146(3):334-7.Noopept stimulates the expression of NGF and BDNF in rat hippocampus.Ostrovskaya RU, Gudasheva TA, Zaplina AP, Vahitova JV, Salimgareeva MH, Jamidanov RS, Seredenin SB.
  24. Bull Exp Biol Med. 2008 May;145(5):610-3.Immunocorrecting properties of GB-115 dipeptide.Shipaeva EV, Kovalenko LP, Khaidukov SV, Kolik LG, Gudasheva TA, Durnev AD, Seredenin SB.
  25. Bioorg Khim. 2008 Sep-Oct;34(5):617-29.Synthesis of cyclic analogues of the nerve growth factor loop 4.Morozova AA, Sumbatian NV, Lezina VP, Akparov VKh, Korshunova GA, Gudasheva TA.
  26. Russian Journal of Organic Chemistry, 2009, vol. 45, No 12, pp. 1829-1833, “Azacycloalkanes: XXXIX. New Syntheses of 1H-Pyrrole-1-carboxylic Acid and 1,2-Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one Derivartives”, G. V. Mokrov, A. M. Likhosherstov, V. S. Troitskaya, T. A. Gudasheva,
  27. Bull Exp Biol Med. 2007 Oct;144(4):543-5.Neuroprotective effect of dipeptide AVP(4-5)-NH2 is associated with nerve growth factor and heat shock protein HSP70.Zenina TA, Gudasheva TA, Bukreyev YS, Seredenin SB.
  28. Bull Exp Biol Med. 2007 Sep;144(3):312-3.Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115.Boyko SS, Kolyvanov GB, Zherdev VP, Gudasheva TA, Kiryanova EP, Seredenin SB

Higher Attestation Commission

Higher Attestation Commission of the Ministry of Education and Science of the Russian Federation

the Ministry of Education and Science of the Russian Federation

The Ministry of Education and Science of the Russian Federation